What Jamie assesses
Skin, routine and sensitivity
- Primary skin concern and intended treatment goal
- Sensitivity and barrier condition
- Current active skincare ingredients
- Recent treatment and sun exposure

Doctor-led polynucleotide treatment · Manchester
Meet Dr Jamie Harrison for a skin assessment and an individual treatment plan focused on skin quality, fine lines and whether polynucleotide injections suit your concerns.
Polynucleotides suitability
Polynucleotides support skin regeneration and overall skin quality without adding facial volume. They may improve hydration, texture, elasticity, firmness and the appearance of fine or crepey lines.
Dr Jamie reviews your skin concerns, medical history, allergies and previous treatments before discussing whether polynucleotides may be appropriate and what your personalised plan would involve. The consultation also considers any current medicines and active skincare.
Your skin and proposed treatment areas are assessed alongside your goals. Dr Jamie then explains the expected benefits, limitations, recovery and follow-up before you decide whether to proceed.
Book an in-person consultation
Review skin texture, fine lines and the areas you would like assessed, alongside your expectations for treatment.
Discuss allergies, prescribed medicines, current skincare and previous procedures so the consultation considers your medical history and individual circumstances.
Discuss preparation, recovery and follow-up, with the product and treatment schedule confirmed before you decide to proceed.
A considered recommendation
A treatment plan should reflect your skin, medical history and the changes you would like to discuss. Dr Jamie considers whether polynucleotides or another approach better suits your concern, explaining the proposed product, appointments and review before you decide.
What Jamie assesses
Practical planning
Your first appointment
Dr Jamie reviews your skin concerns, medical history, allergies and previous treatments before discussing whether polynucleotides could be appropriate and what an individual plan would involve.
Book your consultationDescribe the changes in skin texture or fine lines that concern you and the improvement you would most value personally.
Dr Jamie checks your health, allergies, medicines and past skin treatments, then explains how these may affect your treatment plan.
Your skin and treatment areas are assessed alongside your goals, so the proposed plan reflects your concerns and medical history.
You discuss the product, treatment areas, likely recovery and other options before deciding whether this approach is right for you.
You receive clear guidance about preparation, aftercare, costs and review, with time to ask questions before choosing whether to proceed.
Treatment day
If suitable, Dr Jamie confirms the product and treatment areas before cleansing the skin. Small injections are placed according to the agreed plan, followed by an assessment and clear guidance about aftercare and review.
Book a consultation
Review the agreed product, treatment areas and outcome together before preparation begins and any injections are carried out.
The treatment areas are cleansed before injection, with comfort measures according to the product and your individual needs.
Dr Jamie administers small injections into the agreed areas, checking comfort and the skin throughout the treatment session.
Before leaving, discuss aftercare, expected settling and when to contact the clinic, with a plan for your review.
Recovery and settling
Small raised bumps are often visible for one or two days after treatment. Redness, swelling, tenderness or bruising can also occur while the injection sites settle.
Dr Jamie explains what to expect for the Plinest product and treatment area, provides individual aftercare and tells you when to contact the clinic during recovery.
Injection sites may look raised or feel tender initially. Follow the aftercare advice provided for the product and areas treated.
Small injection bumps can remain visible for one or two days. Contact clinic whenever symptoms worsen or differ from guidance.
Discuss changes at your agreed review rather than judging results immediately. Your response and goals guide the conversation about progress.
Further appointments follow your agreed course and response. Review progress before deciding whether maintenance would be useful for your skin.
Safety and informed consent
Your consultation covers the expected benefits, likely recovery, relevant risks, alternatives and aftercare before you decide whether treatment is right for you.
Small injection bumps, swelling, tenderness or bruising can occur while the skin settles. Dr Jamie explains the likely recovery and how to follow the aftercare guidance from the clinic.
If your recovery feels different from what was discussed, or you are concerned at any point, contact the clinic. Dr Jamie will assess what is happening and explain what to do next.
Before treatment, Dr Jamie explains the expected recovery, relevant risks, alternatives and aftercare, with time for you to ask questions before deciding whether to proceed.

Your doctor
Dr Jamie Harrison personally assesses, plans and performs each proposed polynucleotide treatment at The Rejuvenation Doctors in Bury, Greater Manchester. He bases his recommendation on your anatomy, what you would like to change and the result you want.
As a GMC-registered doctor, Dr Jamie combines medical assessment with a measured approach. He explains what the treatment may improve, its limitations and how the proposed plan relates to your other features or skin goals.
Dr Jamie remains responsible for your treatment record, aftercare and review, so you see the same doctor from consultation through to follow-up.
Patient feedback
“From the initial consultation through to the procedure, Dr Jamie and the team were professional, calm and very reassuring.”
“They made me feel listened to and comfortable throughout. Everything was explained clearly and the care felt personal from start to finish.”
“They came across with warmth and did not push me at all. You are treated like a patient, not a customer.”
Polynucleotides pricing
Plinest polynucleotide treatment costs £250 per appointment. Dr Jamie will confirm your recommended course, treatment areas and complete cost after assessing your skin and priorities.